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A., Harber, M

Meaningful fat reduction typically begins by week three to four as consistent lower calories create a caloric deficit

It is most helpful for: Patients with significant appetite return after GLP-1 discontinuation Those needing a 13 month bridge while transitioning to another long-term therapy (e.g., Contrave) Individuals who previously responded well to it and tolerate stimulants Used strategically, it can help preserve momentum during treatment transitions

This is modest compared to 15% body weight reduction (30+ pounds for many patients) seen with injectable semaglutide 2.4 mg weekly in obesity trials