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neural systems rewrite themselves during observation incomplete state observability (glia, neuromodulators, intracellular states) multiple incompatible timescales (ms days) immature and simplified systems exaggerate drift and stochasticity So what do we do instead
Discussion BARI-STEP, a randomized, placebo-controlled trial, investigated the effect of semaglutide 2.4 mg as an adjunct to lifestyle modification on %WL in patients who had previously undergone MBS with a suboptimal clinical response
In a meta-analysis 6 of eight trials with 60080 patients (ELIXA, LEADER, SUSTAIN-6, EXSCEL, Harmony Outcomes, REWIND, PIONEER 6, and AMPLITUDE-O) , treatment with a GLP-1 receptor agonist led to a 14% relative risk reduction in three-point MACE (HR 086 [95% CI 080093]
It also has a broader binding affinity, affecting other melanocortin receptors beyond just the MC1R responsible for skin pigmentation
The tradeoff is obvious: more volume per injection and fewer doses per vial
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