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Retatrutide, a triple agonist against GLP-1, GIP and glucagon receptors, has demonstrated significant weight loss (up to a 24% reduction in body weight at the highest dose) and metabolic benefits in people with obesity, both with and without type 2 diabetes in phase 2 clinical trials

PMC 6953387

It helps in the activation of an enzyme (GSH transferase B) that plays an important role in detoxification (4)

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But the concept of tissue-specific regulatory peptides that restore normal function rather than suppressing disease processes aligns with the broader goal of immune modulation in autoimmune disease