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Uric acid can modulate cytokine production and inflammatory outcomes through various pathways
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Early animal and small human studies suggest it is generally well tolerated in the short term, but we do not yet have large, longterm trials
Different forms of cell death are closely related, and there are overlapping molecular regulatory pathways between ferroptosis and other cell death modes, such as necroptosis, apoptosis, pyroptosis and autophagy, collectively playing a role in CKD
The treatment requires multiple sessions (typically 510), costs between 40,000 and 1,20,000 for optimal results, and demands ongoing maintenance every 23 months
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