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TRIUMPH-3 (NCT05882045) Design: Phase 3, 80-week, randomised, double-blind, placebo-controlled trial in adults with severe obesity (Class 2 or 3, BMI 35) and established cardiovascular disease, with or without type 2 diabetes

It completely abolishes TG and FFA concentrations and delays the peak in lymph GLP-1 concentrations from 30 to 120 min, with a 75% reduction in the rate at 30 min, but secretion was the same at 60 min (Lu et al., 2012)

The GHS-R1a receptor

The dual GIP/GLP-1 receptor stimulation stops, and hunger signaling reverts to its pre-treatment pattern