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Prolonged glucagon suppression flattens the natural rhythm between feeding and fasting, leading to fatigue, slower repair, and loss of lean mass
MS: literature search, data analysis, and original draft preparation
Eur Heart J 2020;41:255-323
This slow titration approach was used to minimise gastrointestinal side effects and does not represent an approved prescribing schedule
The established Observed Safe Level (OSL) for chronic, long-term supplementation is generally recognized as 2,000 mg per day, though higher doses have been used safely in monitored trials
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