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Ozempic (Semaglutide): Ideal for Type 2 Diabetes with Weight Benefits Though primarily approved for the treatment of Type 2 diabetes, Ozempic has also shown substantial weight reduction benefits in off-label use
2018 Mar 1;103(3):870-881
Purification and characterization of urinary metabolites of alpha-tocopherol
Evaluation of: Glycerol production (a marker of lipolysis) 2-deoxyglucose uptake (a marker of insulin signaling) DNA synthesis (a marker of proliferation) What they found: AOD-9604 stimulated lipolysis dose-dependently from 10 M, with a plateau at 10 M Full hGH stimulated lipolysis to a similar maximum, but with different kinetics AOD-9604 did not affect glucose uptake or DNA synthesis at all, whereas hGH inhibited both (the classic lipotoxic GH effect) Fragments with different sequence (from the N-terminal part of hGH) had no lipolytic effect Why it matters: This was the first publication of AOD-9604
only about 19% of firms with 200 or more workers (and 43% of firms with 5,000 or more workers) covered them in their largest health plan, and some employers have considered scaling that coverage back or adding stricter requirements
