Though the hormone is produced naturally by the body, many people struggle with insufficient GLP-1 production or decreased sensitivity to its effects
For example, glucagon-like peptide-1 agonists (GLP-1) are normally used for the treatment of type 2 diabetes mellitus, obesity, and cardiovascular diseases
Nuclear factor erythroid 2-related factor 2 (Nrf2) functions as a transcription factor and a central regulator of the bodys oxidative stress response 11,12 , so that activating Nrf2 holds promise as an effective therapeutic strategy in OA
CONTRAINDICATIONS According to the package insert, Wegovy is contraindicated in patients with the following: personal or family history of Medullary Thyroid Carcinoma patients with Multiple Endocrine Neoplasm type 2 patients with a prior serious hypersensitivity reaction to semaglutide or to any of the excipients in Wegovy
Additionally, the nausea and vomiting associated with Ozempic can, in rare instances, be severe