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These results suggest that the oxidative stress should be introduced at very early phase in the liver of both groups

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reported lower serum calcium and ferritin, lower HDL cholesterol, and higher LDL cholesterol levels in patients with PG vs controls.20 Premature graying has been linked to early cardiovascular disease, and dyslipidemia may serve as a connecting factor.5 Furthermore, lower vitamin D levels have been reported in patients with PG, although without statistically significant associations.20,27 Regarding copper, lower levels have been observed in PG patients vs controls, but without statistical significance.28,29 Comorbidities Several studies have reported a higher prevalence of atopic diathesis in patients with PG.20,26,30 Das et al

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