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Prevention of HGF nitration-dysfunction offers novel potential to suppress the progression of age-related disorders of muscle homeostasis including muscle atrophy and impaired regeneration accompanied by up-regulation of intramuscular fibrogenesis (fibrosis) and adipogenesis (fat infiltration)
This often occurs in smokers, people with metabolic disease, heavy alcohol drinkers, as a side effect of certain prescription drugs, rheumatoid arthritis and impaired thyroid function
Int J Mol Cell Med
However, all observed effects derive from animal models and in vitro research systems
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