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The patients used six different doses 0 mg (placebo), 1mg, 5 mg, 10 mg, 20 mg and 30 mg

Tachyphylaxis Rapid Exhaustion of the Readily Releasable Pool : The primary neurobiological mechanism driving acute stimulant tolerance is the rapid exhaustion of the readily releasable pool (RRP) of synaptic vesicles (Kaeser and Regehr, 2017

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