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Recently, a real-world study showing association between incretin-based therapy and changes in taste perception with GLP-1 or dual GLP-1/GIP-RAs usage for around 40 weeks reported that independently to weight loss, there was an increase in sweet perception intensity up to 4.7 times and salt perception up to 3.2 times in around 20% of the participants, resulting as well in earlier satiety, and reduction of hunger and craving due to a major sensibilization to both flavors with any of these medication, although they did not mention further impact in weight loss or BMI change (170)
Healthy L-carnitine levels are also associated with improved weight management, exercise performance, and healthy aging
After all, the average responses shown in clinical trials are just that: averages
The ESSENCE trial is an ongoing Phase 3 study investigating the effectiveness of weekly 2.4 mg subcutaneous semaglutide on adults with metabolic dysfunction-associated steatohepatitis (MASH) and moderate-to-advanced fibrosis or liver disease
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