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Its long-term safety record is, by definition, thinner: semaglutide has been prescribed to millions and carries a large post-market safety database, while retatrutide's safety profile is still being characterized in ongoing trials
Primary endpoint: composite of cardiovascular death, myocardial infarction, or ischemic stroke (94), composite of death from cardiovascular causes, non-fatal myocardial infarction, or non-fatal stroke (95), composite of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or hospitalization for unstable angina (96), or time to first occurrence of the composite of cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke (97), respectively
Whether this represents actual tissue repair or simply masked fatigue signals remains unclear
[4] [7] NICE provides guidance on their use within the NHS, typically recommending them when other treatments have not achieved adequate glycaemic control or weight management goals
GLP-1s require ongoing possibly lifelong injections to maintain results
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