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Both are dual agonists that include GLP-1 receptor activation, but they differ fundamentally in their second receptor target: survodutide pairs GLP-1 with glucagon receptor agonism, while tirzepatide pairs GLP-1 with GIP (glucose-dependent insulinotropic polypeptide) receptor agonism
McAtee, who recently opened the Ranch Wellness Center in Orange County, has been prescribing compounded tirzepatide for weight management with regular check-ins for patients, using what he calls microdosing and cycling some of his clients on and off the compounded formulations
This split is important because insurance companies are more likely to cover diabetes medications than weight-loss prescriptions, even when the same drug treats both conditions
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