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The SIERRA open-label phase Ib trial (NCT01952249) was conducted to observe the safety and efficacy of demcizumab (potent inhibitor of the Notch pathway) combined with paclitaxel for the treatment of platinum-resistant ovarian, primary peritoneal, and fallopian tube cancer

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The inhibition of FAO by the knocking down of CPT1 and CPT2 significantly decreased the phosphorylation level of Src and the number of metastatic nodules, confirming the role of mitochondrial FAO and CPT genes in Src regulation and their significance in breast cancer metastasis

10.1016/j.mam.2004.06.004 7 CaoB.JinM.BrietzkeE.McIntyreR

10.1111/dom.12354 12 BauerP