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Interestingly, a placebo-controlled study (6) has shown that substantial elevations (~20%) of muscle carnitine content do occur in humans following prolonged daily supplementation with carnitine tartrate when carbohydrate is ingested at the same time

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Further investigation of the intestinal microbiome metabolism of orally supplemented l-carnitine in patients with IEMs is needed to answer the following questions raised by this study: (1) Does chronic oral l-carnitine supplementation increase the risk of atherosclerosis in individuals with organic acidemias