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Magnetic nanoparticles integrated with reduced graphene oxide offer additional functional advantages for CD44-targeted chitosan systems, including the possibility of magnetic resonance imaging, external field-guided accumulation and hyperthermia-triggered drug release [141, 142]

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The study highlights that PEGylated PLGA nanoparticles, could offer a promising alternative for the safe delivery of tolcapone, maintaining its therapeutic effects while significantly reducing associated hepatotoxicity 129