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223 KD has been reported to exhibit preventative effects on depressive-like behaviors in rodents while its exact mechanism is still unknown

Stopping exercise-induced muscle damage: A huge meta-analysis of 20 different studies showed that creatine monohydrate lowered levels of muscle damage after acute training.[ref] Improving muscle mass in weight training: Quite a few clinical trials show that creatine supplements can help to improve muscle mass while decreasing damage.[ref][ref][ref] Mood disorders: Clinical trials show that creatine may help with depression caused by a lack of brain energy or oxidative stress.[ref] In people with bipolar disorder, 6g/day of creatine was trialed against a placebo

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doi: 10.3389/fpls.2015.00192 Received 30 October 2014 Accepted 10 March 2015 Published 02 April 2015 Volume 6 - 2015 Edited by Richard Sayre, New Mexico Consortium at Los Alamos National Labs, USA Reviewed by Vasileios Fotopoulos, Cyprus University of Technology, Cyprus