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It is the only animotransferase known to utilize SAM as an amino donor Gene Name: BIO3 Uniprot ID: P50277 Molecular weight: 53708.39844 Reactions General function: Involved in methionine adenosyltransferase activity Specific function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP Gene Name: SAM1 Uniprot ID: P10659 Molecular weight: 41818.0 Reactions General function: Involved in catalytic activity Specific function: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (Probable) Gene Name: LIP5 Uniprot ID: P32875 Molecular weight: 46246.80078 Reactions General function: Involved in methyltransferase activity Specific function: Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate and 3-isopropylmalate at high affinity and of other molecules like cis-aconitate, isocitrate, and citrate at lower velocities and affinities

Spontaneous transmembrane helix insertion thermodynamically mimics translocon-guided insertion

Thunor 35 was used to fit dose-response curves and the area over the curve (Activity Area) was calculated to reflect the potency of cell killing 35

Its sleep effects are modest, but they are consistently measurable in humans

This is critical