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GLP-1 faces toward TM5 to form cation-pi stacking and hydrogen bond with the rotated down side-chain of R299 ECL2 , while that of W306 5.36b and R310 5.40b switch out from the receptor core to accommodate the approaching of histidine

Based on these two cases and knowing from both patients and literature that no good medical therapies exist for the millions of people suffering from this debilitating disease, we designed this randomized, controlled trial

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