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As scientists continue to push forward with new drugs and grapple with questions about what exactly these drugs are doing, Jakicic hopes that everyone remembers one important truth: Muscle health is very different from muscle volume. When voluntarily losing weight, the goal should not be to preserve muscle mass entirely, but rather to limit unnecessary muscle loss and improve muscle function

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Notably, unpaired cysteines have been intentionally introduced in mAbs for site-specific conjugation as part of antibody-drug conjugate strategies (e.g., ThiomAbs)