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These cytokines are produced by adipose tissue macrophages in proportion to the amount of visceral fat
Clinical efficacy remains limited, and interpretation of results is compromised by the lack of standardization when using different strains (even within the same species), the inability to determine individual contributions in multi-strain formulations and the lack of consistency in dosage and duration of probiotic use
It is typically more suitable for lighter skin types and requires proper assessment to determine appropriateness
However, clinical translation still faces challenges, such as administration routes, dosage optimization, and toxicity assessment, which require further investigation
