Do You Need Protein Supplements on GLP-1
Discussion This observational cohort study describes real-world utilization patterns and characteristics of patients dispensed an SGLT2i or GLP-1 RA in the US using data from Optum CDM in the period following changes to the landscape for treatment and prevention of CKD in type 2 diabetes (later period, July 2021September 2023) as well as temporal changes in utilization and baseline characteristics relative to the period prior (earlier period, January 2012June 2021)
IHC revealed decreased -synuclein protein levels, indicating reduced neuronal damage, and increased brain-derived neurotrophic factor (BDNF) levels, confirming neuroprotection
Notably, the observed variability in efficacy between agents, particularly in the early phases of treatment, emphasizes the importance of individualized therapeutic strategies, tailored to specific clinical goals, baseline metabolic profiles, and patient preferences
^ Advances in Clinical Chemistry