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For best results, wear the patch for up to eight hours and then remove it carefully

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Most of the drugs efficacy is lost as it passes through the physiological barriers of the digestive system, leading to low drug utilization efficiency [38, 148, 149] ( Fig

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Recent research has shown that metformin may also have therapeutic potential beyond diabetes, including the treatment of chronic pain, cancer, and polycystic ovary syndrome

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Injectable use has a growing body of anecdotal evidence and practitioner experience, though large-scale human trials for injectable forms are still limited

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