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In the NTS model, Glp1r / mice exhibited immunomodulatory effects, increasing tissue infiltration of neutrophils and T cells

Lower estrogen levels also play a role in where fat is distributed, leading to more weight gain around the midsection as opposed to other areas

These predispositions do not determine outcome but may provide context for provider conversations about optimal dosing approach and expected response timeline

Retatrutide is an investigational triple receptor agonist that simultaneously activates GLP-1, GIP, and glucagon receptors to address multiple aspects of metabolic dysfunction

However, a false positive skin test result is possible given the limitations of skin testing with subcutaneous agents