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Y., Shi, H

PET scans have revealed a significant reduction in dopamine levels in the striatum, including the caudate nucleus and putamen, which disrupted dopamine signaling

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The effect of TZDs on insulin sensitivity is mediated by the activation of PPAR, a nuclear receptor that regulates the transcriptions of several genes involved in glucose and lipid metabolism and energy balance and increases fat oxidation, adipocyte proliferation, lipogenesis, fat redistribution, and reduces plasma free fatty acid and pro-inflammatory cytokine levels [159]

Currently, the 7 antiobesity medications (AOMs) approved by the FDA to treat obesity are phentermine, orlistat, phentermine/topiramate extended release (ER), naltrexone sustained release (SR)/bupropion SR, liraglutide (3.0 mg), semaglutide (2.4 mg), and tirzepatide