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Non-alcoholic fatty liver disease (NAFLD): assessment and management (NG49) Recommendations chapter
It belongs to a novel class of agents known as triple receptor agonists, meaning it simultaneously activates three distinct hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors
(Source: iPharma Pharmacy, 2026) Tirzepatides Dual Mechanism May Offer a Compliance Advantage Because tirzepatide activates both GLP-1 and GIP receptors, researchers have hypothesized its dual mechanism may reduce the intensity of gastrointestinal side effects compared to single-receptor GLP-1 agonists a meaningful consideration since GI side effects are a leading cause of treatment discontinuation
Report of a WHO consultation
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