In theory, exogenous KLOW administration should enhance insulin sensitivity by improving GLUT4 translocation, reduce oxidative stress via upregulation of superoxide dismutase, and support mitochondrial biogenesis through AMPK pathway activation
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As an important component of regulating metabolism and immune homeostasis, the vagus nerve can regulate WAT content through the central nervous system to control sympathetic peripheral muscle bundles, and can also regulate the release of GSH and NO to enhance antioxidant capacity and prevent ferroptosis (36)
In mammals, CAC can accept acylcarnitines with acyl chains of various lengths from 2 to 18 carbon atoms as substrates, but it showed a higher affinity for acylcarnitines with longer carbon chains (Indiveri et al., 2011)