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Individuals using GLP-1 medications may experience: Reduced caloric and protein intake Early satiety or nausea Gastrointestinal changes that affect absorption Increased fatigue during metabolic adjustment Because B-complex vitamins support energy metabolism, neurological pathways, and gastrointestinal integrity, supportive supplementation may be considered when intake is reduced or oral tolerance is limited

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In other words, even though no major risks have been found, more studies need to be done

It also lacks the intense hunger stimulation that makes some GH secretagogues problematic during weight loss protocols