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They found that semaglutide was linked to a 28% reduction in major adverse cardiac events (12.3% in the placebo group had such events compared to 9.1% in the semaglutide group), as well as a 24% reduction in cardiovascular disease-related deaths for this subgroup of people with pre-existing heart failure, and a 19% reduction in deaths of any cause

If retatrutide receives marketing authorisation in the future, it would likely be subject to additional monitoring indicated by a black triangle () symbol which encourages enhanced Yellow Card reporting for new medicines to help identify any rare or delayed effects not captured in pre-approval trials