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Can aid our body's ability to bind harmful compounds
Click on the JSmol tab to take a closer look at how GLP-1 (PDB 6X18), semaglutide (PDB 7KI0), tirzepatide (PDB 7FIM), and orforglipron (PDB 6XOX) are able to stabilize the active form of the GLP-1 receptor, and compare these structures to that of the inactive GLP-1 receptor (PDB 6LN2)
In the tirzepatide SURMOUNT-1 body-composition substudy, 26 percent of the weight people lost was lean mass, and in that same study, people in the placebo group who lost weight without any drug lost 25 percent of theirs as lean mass (Look et al., 2025)
10.1002/jcp.29204 114
Therapeutic Advances in Endocrinology and Metabolism 16
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