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It should not be called a selective MC1R-only ligand
A reasonable candidate is someone who: Is already following a structured, clinician-supervised nutrition and activity plan Has a documented B12 deficiency or a condition that impairs B12 absorption Cannot tolerate GLP-1 medications, or is not a candidate for them Declines prescription pharmacotherapy and wants a non-stimulant, non-surgical adjunct Understands because the clinician has said so plainly that the injection is a supporting player A poor candidate is someone who wants the shot instead of the program
This can also prevent sports related injuries because of less fatigue
In trials, they typically achieve significant weight reduction (1520% body weight) and improved glucose control
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