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10.1038/415096a 12 FengY.FanJ.LinX.YangJ.CuiQ.TangX.et al (2017)
Extensive evidence suggests that LA may have therapeutic usefulness in lowering blood glucose levels in diabetic conditions and that the intracellular redox status plays a role in the modulation of insulin resistance
(1) Metformin upregulates the small hetero-dimer partner through the AMPK signaling pathway, which interacts directly with the cAMP-response-element-binding factor (CREB) to block the recruitment of CREB to CREB-regulated transcription co-activator 2 (CRTC2), downregulating the expression of gluconeogenic genes (4)
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