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For the in vitro experiments, a murine macrophage cell line RAW 264.7 was used
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The peptide triggers gene expression changes in over 4,000 genes that persist beyond the moment of injection (Pickart & Margolina, 2018)
Superiority testing followed a hierarchical order, beginning with the highest Cagrilintide dose versus placebo, using a two-sided 5% significance threshold
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