As well, in real-world scenarios, such as described by Brindisi et al, it is mentioned a reduction in pleasure and taste perception in overweight and people with obesity with poor type 2 diabetes control, probably by lowering the detection threshold of sweet flavors, becoming more sensitive to them, resulting in aversion for this flavor (175)
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Next, because TLR9 activation requires endosomal maturation and Munc13-4 deficiency was associated with reduced maturation and impaired endolysosomal degradative capacity 16 , we analyzed the effect of ENDO3 on endolysosomal activity
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