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[4] [6] Medication review: A thorough review of concomitant medicines that may independently raise heart rate is advisable, including sympathomimetics, SNRIs, tricyclic antidepressants, and beta-2 agonists Lifestyle measures: Reducing caffeine intake, managing stress, and ensuring adequate sleep can all contribute to heart rate regulation Cardiac monitoring: In patients with pre-existing cardiac conditions, an electrocardiogram (ECG) or ambulatory heart rate monitoring may be warranted Specialist referral: If tachycardia persists or is associated with arrhythmia, referral to a cardiologist should be considered In some cases, if the heart rate elevation is persistent and symptomatic despite dose adjustment, discontinuation of retatrutide may be necessary

People with diabetes should ask whether glucose targets or other medicines need adjustment

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