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Upcoming CVD outcome trials, such as the EXSCEL study of exenatide weekly, the LEADER study of liraglutide and the REWIND study of dulaglutide might provide further insight in this matter (Table 1)

Concerns have been raised that the rate of DKA in real-world practice would surpass rates seen in closely supervised RCTs [37]

Tran said there was also no muscle loss observed with NA-931 in the trial

On top of that, berberine stimulates endogenous GLP-1 secretion from L-cells in the intestinal lining through bitter taste receptor activation