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Laboratory studies demonstrate that elimination of senescent cells through FOXO4-DRI administration can break the cycle of senescence induction and chronic inflammation, offering insights into interventions for age-related cellular dysfunction and tissue deterioration
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Rubicon depletion in adipocytes was also shown to reduce body weight and sWAT, vWAT, and BAT mass [83], indicating that inhibiting autophagy may postpone metabolic diseases during aging
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