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Ann Intern Med 2005
The minimal side effects observed were mainly flares of MCAS-driven symptoms in response to initial dosing, which were easily managed with extra doses of H1/H2 receptor blockers
References: Chan A, Paskavitz J, Remington R, Rasmussen S, Shea TB
Metformin has been shown to reduce TMA and TMAO levels by remodeling gut microbiota
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