glp 1 risks reddit What we still don't know about weight-loss drugs Understanding the Risks of GLP-1

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Thorpe, K et al JAMA Network Open December 5, 2024 The evidence that GLP-1 medications are effective at weight loss and reducing metabolic disease burden in those with obesity continues to mount, but only about 52% of employers currently cover these drugs for obesity, and these employers are facing escalating costs

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Consistent findings have shown that GLP-1R agonism promotes weight loss and improves glucose homeostasis in rodents, monkeys and humans (reviewed in Barrera et al., The anatomical distribution of the endogenous GLP-1 system GLP-1 is derived from the preproglucagon gene

Mental health: While rare, there have been studies that showed patients who have had a history of suicidal ideations start to have recurring thoughts of self-harm while taking this class of medication (GLP-1s)