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However, GLP-1RAs should be considered as the preferential add-on therapy in T2DM patients with CKD in case of persistent albuminuria and/or uncontrolled metabolic risks (i.e., inadequate glycemic control, hypertension, overweight/obesity)

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Medications are initiated at low doses and gradually increased over several weeks to minimise gastrointestinal side effects such as nausea and vomiting

Nonetheless, endogenous and exogenous CCK (mostly CCK-8) acts on VANs to decrease meal size 170,171

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