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These encompass nuclear hormone receptor agonists, fibroblast growth factors 19 and 21, incretins (single, dual, or triple), sodium-glucose cotransporter inhibitors, and agents modulating metabolic pathways

ROS exert their harmful effects by deactivating enzymes, oxidizing proteins, damaging DNA, initiating lipid peroxidation, and denaturing proteins

A systematic review of drug-drug interactions with GLP-1RAs found that most co-administered oral drugs did not experience clinically significant changes in total exposure (AUC), although reduced peak concentrations (Cmax) and delayed time to peak (Tmax) were commonly observed, particularly for drugs with high solubility and permeability (108)

On average, people taking Saxenda in clinical trials lost about 5-7% of their body weight (10 to 14 pounds for someone who weighs 200 pounds) More than one in four clinical trial participants lost over 10% of their body weight and about one in seven lost over 15% of their body weight

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