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The pathogenesis of SLE is intricate, involving cells from both the innate and adaptive immune systems ( Figure 2 )
This peptide hormone, composed of 39 amino acids, has both GIP (Glucose-dependent Insulinotropic Polypeptide, also known as Gastric Inhibitory Polypeptide) and GLP-1RA (Glucagon- Like Polypeptide -1 Receptor Agonist) features
Codon optimised sequences of NAPstar3b and HyPer7 for expression in mammalian cells were commercially synthesised (Supplementary Table 4) (GenScript Biotech, Rijswijk, Netherlands) and delivered in pcDNA3.1(+) plasmids
It can stem from several factors
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