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Other mechanisms In addition to the aforementioned well-established therapies, numerous other pharmacological agents, chemical compounds, proteins, and methodologies that have not yet been implemented in clinical practice are currently being investigated to restore the Th17/Treg balance to treat AR (Table 6)

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By persistently reducing nutrient inflow while maintaining or redistributing oxidative demand, GLP-1RA therapy establishes a state of chronic energy flux constriction