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20 There is one early blinded, placebo-controlled trial of NAC on its own in 43 patients with Alzheimers disease that found NAC, 50 mg per kg bodyweight (equivalent to 3750 mg for a person weighing 75 kg) per day for 6 months, to be superior to placebo in almost all outcome measures, although not all reached statistical significance

Essential for hormones, brain health, and absorbing vitamins, so it is never something to cut out entirely

So its a case of leapfrogging and iterative improvement

Harris, R

These modifications result in a longer half-life (approximately 2030 hours) and reduced binding to IGF-binding proteins, making it about three times more potent than native IGF-1