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Thermogenesis increases slightly
Eating high-fat meals (like fried food or full-fat dairy) can slow it down furtherleading to uncomfortable side effects like nausea or bloating
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Taken together, these pooled safety analyses (119123) and CV outcome safety trials (124127), together with review of published data from numerous clinical trials (39), provide reassuring evidence that the catalytic activity of the DPP-4 molecule can be modulated to enhance the beneficial metabolic effects of its substrates (such as the incretin hormones) without adversely affecting any of the protease-independent metabolic effects discussed above, or interfering with any of its other (non-metabolic) functions
These findings support its inclusion in experimental longevity research discussions
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