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Oral lipoic acid supplements are better absorbed on an empty stomach than with food: taking lipoic acid with food (versus without food) decreased peak plasma lipoic acid concentrations by about 30% and total plasma lipoic acid concentrations by about 20% (8)

Carboplatin (CARB) is a widely used platinum-based chemotherapeutic agent with a broad spectrum of clinical activity against various malignancies, including gynecological cancers, germ cell tumors, head and neck cancers, and bladder cancer.1 Although structurally related to cisplatin, carboplatin has a significantly lower toxicity profile.2 Approved by the U.S

The most relevant systematic review found 36 studies, but 35 were preclinical and only 1 was clinical, with no large human efficacy trials identified [4]

doi: 10.1172/jci.insight.174639 107 LefereSPuengelTHundertmarkJPennersCFrankAKGuillotAet al