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Frequently Asked Questions Can someone with a normal BMI safely use GLP-1 medications like semaglutide or tirzepatide
However, research has shown that there may be more complicated mechanisms not restricted to dopaminergic signaling and the brain-gut axis, such as insulin receptors in the brain, single nucleotide polymorphisms (SNP), and neuroplasticity (68)
Furthermore, the ZSF1 rats leptin receptor mutation contributes to a profound state of hyperphagia, which may indirectly impact GLP-1 action by necessitating a higher threshold for appetite suppression compared to the wild-type phenotype
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The SURMOUNT trials reported mean weight loss exceeding 20% at the highest tirzepatide doses
