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Calorie restriction inhibits ovarian follicle development and follicle loss through activating SIRT1 signaling in mice
Mechanistically the peptide is hypothesised to act as a 'gene-regulatory short peptide': because of its small size it is proposed to reach the nucleus intact and to bind DNA at specific motifs
They are composed of various proteins, including claudins, occludin, and junctional adhesion molecules, which work together to seal the spaces between epithelial cells
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