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Horovitz A, Fleisher RC, Mondal T (2019) Double-mutant cycles: new directions and applications
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This antinociceptive profile may reflect DSIPs interaction with endogenous opioid peptide systems and/or NMDA receptor modulation at spinal cord and supraspinal pain processing sites
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While systemic injection also delivers peptides to the brain via blood circulation, nasal delivery may provide more direct CNS access for some portion of the dose
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In that case, an overnight excursion outside the fridge is more concerning
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